Cyclin D and cyclin E expression in normal and adenomatous pituitary
نویسندگان
چکیده
منابع مشابه
Cyclin D and cyclin E expression in normal and adenomatous pituitary.
OBJECTIVES Cyclins play an important role in the regulation of cell progression through the cell cycle. Over-expression of the cyclins has been shown in many different tumour types. Pituitary adenomas are a common form of endocrine neoplasia in the human, but have been little studied in terms of the expression of the principal cyclins regulating checkpoint exit, cyclin D1 and cyclin E. METHOD...
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Normal, nontumorous cells express cyclin proteins in an orderly, scheduled fashion, at a given phase of the cell cycle. Thus, cyclin B1 is synthesized during G2 and abruptly degraded during mitosis. The onset of cyclin E synthesis takes place in mid-G1, its maximal expression is at the time of cell entrance to S, and its degradation occurs during cell progression through S phase. In the present...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2000
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.143r001